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Cake day: June 6th, 2023

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  • IrritableOcelot@beehaw.orgtoScience Memes@mander.xyzIt hurts me.
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    2 days ago

    Yep! The LD50 is 12.5% in air (higher than I thought, honestly) and yes the issue is that it binds preferentially to hemoglobin.

    The main treatment for sub-lethal exposure is just supplying pure oxygen to kick the equilibrium the other way and slowly remove the CO from your system. It won’t all come off, but your body recycles red blood cells pretty quickly, so you’re back on your feet within a few hours and back to normal within a few days. However, there’s no treatment for lethal doses, people have proposed using things like cobalt porphyrins (which bind CO even better than iron hemes) to more quickly sequester the CO from your hemoglobin, but that’s not been trialled yet in humans.

    I wasnt aware of its use as a neurotransmitter (but I’m absolutely going to look into it now), but its barely soluble in water so there must be more going on there. just like urea, it’s a natural waste product, and typically one your body wants to get rid of reasonably quickly.

    Edit: from a chemical perspective, NO and CO “look” electronically similar to a NO-binding protein, so I expect most of these effects of CO are actually just it activating pathways natively activated by NO.






  • Well, the size estimate on flathub assumes that you’re installing every dependency, which only happens if it’s the first app you’re installing with this FreeDesktop version, which is rare. I have like 15 flatpak apps installed, all of which had a claimed install of over “1 GB”, but the flatpak install directory is only like 2 or 3 GB.

    There’s just not a great way to predict how big an install will actually be from flathub.

    Edit: just to give you an idea, since its only downloading the deltas, most of these “1 GB download size” Flatpak apps are downloading less than 100 MB