IMHO not really.
There is the slight chance that DBs get inconsistent with backing up hot DB files, but in a homelab with minimal load this is usually not an issue. Same for NFS.
Just make sure you have older backups, too. Just in case the last backup was not good.
Nomad is totally fine to run on low-spec machines. On my homelab, I have the following running Nomad + Consul:
Totally fine to run client and server on the same machine in a non-enterprise setup.
One stand-alone machine should also work, you just lose the failover capabilities.