Years ago I tried modding Fallout New Vegas and I think 4 on Fedora ages (I was running Fedora 28 at the time) ago using Mod Organizer 2 and it wouldn’t work for reasons I didn’t understand, possibly file system related. I’m thinking of switching to Pop! OS full time but I’d still like to play either modded Skyrim or FO4 from time to time, preferably using MO2.
I’m currently playing through fallout 4 with mods. the hardest part was figuring out how to install MO2 and make it recognize Fo4 on steam, I followed the guide here: https://github.com/rockerbacon/modorganizer2-linux-installer
after that, installing mods are the same as on windows.